Botox vs. Restylane vs. Juvederm or Other Cosmetic Fillers: Which is Right for You?

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Botox vs. Juvederm vs. Restylane

Botox vs. Resylane vs. Juvederm

Injectables and fillers like Botox®, Restylane®, and Juvederm® are increasingly popular tools in the anti-aging skin care arsenal. According to the American Society for Aesthetic Plastic Surgery, their use increased 40% from 2010-2015 with 6.6 million Americans using Botox® or a cosmetic filler in 2015.

Why are these age-defying powerhouses trending? It’s because injectables and fillers hit an anti-aging sweet spot. Unlike topical skincare products, they deliver anti-aging benefit under the skin. Yet, unlike plastic surgery, they are noninvasive and promise to erase signs of aging without the host of risks and downtime that comes with a facelift.

But, with 22 FDA-approved fillers alone out there, it can be hard to pinpoint which injectable or filler will work for your particular aging concern. So Botox vs. Resylane vs. Juvederm? Here’s help to figure out what’s right for you:

Botox® Injectable

How Botox Works:

Botox is considered the gold standard of injectables and was the first injectable to be approved by the FDA in the 1980s. It relaxes muscles and smooths wrinkles by temporarily paralyzing the muscles with an injectable neurotoxin. Other neurotoxins include Dysport and Xeomin.

What’s Botox Best for?

Crow’s feet, forehead lines, glabella (between the eyes) and frown lines

How Long Does Botox Last?

3-4 months

Fillers: Juvederm Ultra®, Belotero Balance®, and Restylane Defyne®

How They Work:

These fillers act like your body’s own hyaluronic acid, restoring a youthful appearance by filling out superficial folds, restoring volume to the face and improving fine lines and wrinkles.

Works On:

Mild to moderate nasolabial folds, marionette lines, and chin wrinkles.

Lasts for:

Juvederm® Ultra and Belotero®, 6-12 months; Restylane®, initial treatment last 6 months with subsequent injections lasting up to 18 months or more. *


Fillers: Juvederm® Voluma and Restylane® Lyft

How They Work:

Thicker than other hyaluronic fillers, Juvederm Voluma and Restylane Lyft are designed to give sturdy structure to the face.

Best for:

Plumping and restoring volume to the cheeks.

Lasts for:

14-16 months.


Fillers: Juvederm®Ultra Plus and Radiesse®

How They Work:

With a larger particle size, these fillers can be placed farther below the surface of the skin to plump up deeper folds and wrinkles and provide greater structure to areas of the face that have lost volume.

Best for:

Restoring the coveted V-shape contour of youth, softening deeper nasolabial folds, marionette lines and smoothing chin wrinkles.

How long they last:

Juvederm Ultra Plus, 6-12 months, Radiesse, 12 months. *

Restylane® Silk Filler

How Restylane Silk Works:

This hyaluronic acid filler was approved by the FDA in 2014. It is often paired with a super-fine needle to minimize bruising on the sensitive skin of the lips. It’s known to plump lips and minimizes fine lines around the mouth.

What Restylane Silk Works for:

Lips and mouth.

How Long Does Restylane Silk Last:

6-9 months.


No one treatment is best for everyone. Smooth Synergy® Cosmedical Spa prides itself on providing customized treatment plans that take each client’s individual skincare needs into consideration. Please call us at 212-397-0111 to schedule a consultation with one of our experts in beauty and get a better understanding of which injectable or filler is right for you.

*These fillers can last about a year at full correction.
(Please note that this information is to serve as a guide only and is no substitute for making an appointment for a consultation with an expert in beauty at Smooth Synergy®, who is knowledgeable about how to layer modalities for maximum benefit to the skin and who can speak to your individual skincare concerns.)

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